Cox10-Flox

系統名

C57BL/6Smoc-Cox10em1(flox)Smoc

SMOC番号

NM-CKO-240103

維持形態

Developing

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遺伝子の概要

Gene Symbol
Cox10

Synonyms

AU042636; 2410004F01Rik

NCBI ID

70383

MGI ID

1917633

Ensembl ID

ENSMUSG00000042148

Pubmed

Cox10

Human Ortholog

COX10

説明

These strains carry loxP sites flanking exon 6 of Cox10 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cox10 gene.

病気の予測

Parkinson's Disease

表現型

MGI:5775427
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc6a3-cre mice.

参考文献

Pinto M, Nissanka N, Peralta S, Brambilla R, Diaz F, Moraes CT, Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation. Mol Neurodegener. 2016;11:25

Mitochondrial Myopathy

表現型

MGI:3609951
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myl1-Cre mice.

参考文献

Diaz F, Thomas CK, Garcia S, Hernandez D, Moraes CT, Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum Mol Genet. 2005 Sep 15;14(18):2737-48

Cytochrome-C Oxidase Deficiency Disease

表現型

MGI:5444474
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Camk2a-cre mice.

参考文献

Diaz F, Garcia S, Padgett KR, Moraes CT, A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Hum Mol Genet. 2012 Dec 1;21(23):5066-77

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