Fgfr3-Flox

系統名

C57BL/6Smoc-Fgfr3em1(flox)Smoc

SMOC番号

NM-CKO-2101148

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Fgfr3

Synonyms

FR3， Mfr3， sam3， CD333， Flg-2， HBGFR， Fgfr-3

NCBI ID

14184

MGI ID

95524

Ensembl ID

ENSMUSG00000054252

Pubmed

Fgfr3

Human Ortholog

FGFR3

説明

These mice carry loxP sites flanking exon 3-7 of Fgfr3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fgfr3 gene.

病気の予測

Lung Cancer

表現型

MGI:5141741
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ctnnb1-Flox(NM-CKO-200154) and Upk2-cre mice.

参考文献

Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T, K-Ras and {beta}-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech. 2011 Jul-Aug;4(4):548-55

Thanatophoric Dysplasia

表現型

MGI:3640323
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Col2a1-cre mice.

参考文献

Iwata T, Chen L, Li Cl, Ovchinnikov DA, Behringer RR, Francomano CA, Deng CX, A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet. 2000 Jul 1;9(11):1603-13

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