Fgf23-KO(2)

系統名

C57BL/6Smoc-Fgf23em1Smoc

SMOC番号

NM-KO-210211

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Fgf23

Synonyms

-

NCBI ID

64654

MGI ID

1891427

Ensembl ID

ENSMUSG00000000182

Pubmed

Fgf23

Human Ortholog

FGF23

説明

Exon 2 of Fgf23 gene was deleted to generate Fgf23 knockout mice

病気の予測

Autosomal Dominant Hypophosphatemic Rickets

表現型

MGI:3512452
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Phex-KO(NM-KO-2114546) mice.

参考文献

Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, J Apw-Ppner H, Lanske B, Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004 Nov;23(7):421-32

X-Linked Dominant Hypophosphatemic Rickets

表現型

MGI:3653482
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Phex-KO(NM-KO-2114546) mice.

参考文献

Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD, Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E38-49

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