Cdkn1a-KO

系統名

C57BL/6Smoc-Cdkn1aem1Smoc

SMOC番号

NM-KO-190774

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Cdkn1a

Synonyms

P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1

NCBI ID

12575

MGI ID

104556

Ensembl ID

ENSMUSG00000023067

Pubmed

Cdkn1a

Human Ortholog

CDKN1A

説明

Exon 2-3 of Cdkn1a gene was deleted to generate Cdkn1a knockout mice.
応用分野：Mice that lack this gene have the ability to regenerate damaged or missing tissue.

病気の予測

Systemic Lupus Erythematosus

表現型

MGI:3618363
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Gadd45a-KO(NM-KO-200590) mice.

参考文献

Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, Ashwell JD, Fornace AJ, Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome. Immunity. 2002 Apr;16(4):499-508

Hepatocellular Carcinoma

表現型

MGI:3046808

参考文献

Wang Y, Cui F, Lv Y, Li C, Xu X, Deng C, Wang D, Sun Y, Hu G, Lang Z, Huang C, Yang X, HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology. 2004 Feb;39(2):318-24

Systemic Lupus Erythematosus

表現型

MGI:3615496

参考文献

Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, Ashwell JD, Fornace AJ, Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome. Immunity. 2002 Apr;16(4):499-508

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