Ace2-KO

系統名

C57BL/6Smoc-Ace2em1Smoc

SMOC番号

NM-KO-190906

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
ACE2

Synonyms

ACEH

NCBI ID

59272

MGI ID

Null

Ensembl ID

ENSG00000130234

Pubmed

ACE2

Human Ortholog

ACE2

説明

exon 3-7 of Ace2 gene was deleted to generate Ace2 knockout mice.
応用分野：regulation of cardiovascular and renal function, as well as fertility , Cardiac contraction, colitis, cardiovascular and renal function, and fertility

病気の予測

Congestive Heart Failure

表現型

MGI:2661730

参考文献

Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM, Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 2007 Jul 1;75(1):29-39

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