Crbn-I391V
系統名
C57BL/6Smoc-Crbnem1(I391V)Smoc
SMOC番号
NM-KI-200331
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
Crbn
説明
表現型データ
Fig1. CRBN modulators induced IL-2 secretion and Aiolos degradation in Crbn-I391V point mutation mice.
（A）Analysis of IL-2 production in naive CD4+ T cells by ELISA. After Lenalidomide 5000nM or Pomalidomide 5000nM treatment, CRBN modulators induced IL-2 secretion in naive CD4+ T cells.（B）Analysis of Aiolos expression in the spleen by FACS. After Lenalidomide 10uM or Pomalidomide 5000nM treatment, the AIOLOS expression decreased obviously in CD19+ B cells and CD3+ T cells. The results have shown that this Crbn-I391V KI mice model can be used to study the in vivo toxicity and efficacy of CRBN target drugs. (In collaboration with partners)
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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