hFcRn(SD)

系統名

SD-Fcgrtem1(hFCGRT)Smoc

SMOC番号

NR-HU-200002

維持形態

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遺伝子の概要

説明

The endogenous rat Fcgrt gene was replaced by human FCGRT gene.
応用分野：cancer research,Immunotherapy,drug screening

表現型データ

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Fig1. Expression characterization of hFCRN in hFCRN knockin rat by Western blot. 

Abbr. HO, homozygous; WT, wild type.

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Fig2. PK study of Keytruda in hFCRN rat.

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Fig3. PK study of Cyramza in hFCRN rat.

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Fig.4  Blood concentration curve of test articles in hFcRn/hALB dKI rats (NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). 

In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party) image.png

Fig.5 PK study of Keytruda in  hALB/hFCRN dKl rat (NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). (n=3/time point/group) 

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Fig.6 PK study of Cyramza in hALB/hFCRN dKI rat(NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). (n=3/time point/group)  

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