R26-CAG-LSL-mCherry-EGFP-LC3
系統名
C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-mCherry-EGFP-Map1lc3a-pA)Smoc
SMOC番号
NM-KI-00124
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Gt(ROSA)26Sor
説明
表現型データ
Fig1. Detection of EGFP and RFP fluorescence intensity in brain, heart and liver tissues of R26-CAG-mCherry-EGFP-LC3 mice. Starvation(+): The mice were fasted for 48 hours; Starvation(-): The mice were fed normally.
Fig2. Detection of EGFP and RFP puncta in liver tissue sections of R26-CAG-mCherry-EGFP-LC3 mice. Starvation for 48 h increased the ratio of RFP/EGFP fluorescence expression in liver tissue of R26-CAG-mCherry-EGFP-LC3 mice. These results suggested there was increased fusion of autophagosomes with lysosomes after 48h starvation. Starvation(+): The mice were fasted for 48 hours; Starvation(-): The mice were fed normally.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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