Slc17a6-IRES-Cre

系統名

C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc

SMOC番号

NM-KI-200087

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Slc17a6

Synonyms

DNPI; VGLUT2; 2900073D12Rik

NCBI ID

140919

MGI ID

2156052

Ensembl ID

ENSMUSG00000030500

Pubmed

Slc17a6

Human Ortholog

SLC17A6

説明

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.
応用分野：Cre recombinase tool; The glutamate transporter 2 gene (Vglut2/Slc17a6) is expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

表現型データ

image.png

Fig. 1 Cre-mediated recombination in the brain of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and thalamus derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the retina of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Slc17a6Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, striatum and thalamus. TdTomato can also be detected in individual cells of the retinal ganglion cell layer and extranet layer, pituitary gland, heart, kidney, testis, epididymis, brown fat, thymus, spleen, stomach, skeletal muscle, intestine, colon, salivary gland and pancreas islet. Tdtomato expression can not be observed in the lung, liver or skin. (For more detailed information please contact our technical advisor.)


出版物

Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus–thalamus circuitry
References：PNAS

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