Muc2-2A-CreERT2-IRES-tdTomato

系統名

C57BL/6Smoc-Muc2em1(2A-CreERT2-tdTomato-Wpre-pA)Smoc

SMOC番号

NM-KI-200301

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol

Synonyms

MCM，wnn，2010015E03Rik

NCBI ID

17831

MGI ID

1339364

Ensembl ID

ENSMUSG00000025515

Pubmed

Human Ortholog

MUC2

説明

2A-CreERT2-tdTomato-Wpre-pA expression cassette was knocked into the Muc2 gene stop codon site.

表現型データ

image.png

Fig 1. Active tdTomato expression was observed in the large intestine of Muc2CreERT2-IRES-tdTomato/+  mouse. WT, wild type as control.

image.png

Fig 2. Active tdTomato expression was observed  in the small intestine of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

image.png

Fig 3. No obvious tdTomato signal was observed in the stomach of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

image.png

Fig 4. Active tdTomato signal was observed in the colon of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

image.png

Fig 5. Active tdTomato signal was observed in the cecum of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

image.png

Fig 6. TdTomato signal was observed in the small intestine of Muc2CreERT2-IRES-tdTomato/+ mouse.WT, wild type as control.


image.png

Fig 7. No obvious tdTomato signal was observed in the stomach of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

参考文献

Slowed Intestinal Transit Induced by Less Mucus in Intestinal Goblet Cell Piezo1-Deficient Mice through Impaired Epithelial Homeostasis
References：MDPI

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細