Slco1c1-2A-CreERT2

系統名

C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc

SMOC番号

NM-KI-200262

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Slco1c1

Synonyms

Oatp2; Oatpf; OATP-F; OATP-14; Slc21a14

NCBI ID

58807

MGI ID

1889679

Ensembl ID

ENSMUSG00000030235

Pubmed

Slco1c1

Human Ortholog

SLCO1C1

説明

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.
応用分野：Ischemic infarction

表現型データ

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Fig. 1 CreERT2-mediated recombination in the choroid plexus of Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 Labeling was also observed in the retina, muscles, but not in pituitary, heart, lungs, stomach, submandibular gland, brown fat, kidney, pancreas, small and large intestine, spleen, skin, ovaries and uterus.（For more information please contact: 400-728-0660.）

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