Cd19-IRES-DTRGFP

系統名

C57BL/6Smoc-Cd19em2(IRES-DTREGFP)Smoc

SMOC番号

NM-KI-190042

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
CD19

Synonyms

AW495831

NCBI ID

12478

MGI ID

88319

Ensembl ID

ENSMUSG00000030724

Pubmed

CD19

Human Ortholog

CD19

説明

A IRES-DTREGFP expression cassette was knocked into the Cd19 gene stop codon site.
応用分野：DTR mouse

表現型データ

Validation data of EGFP expression

Cd19-1.png

Fig1.  Validation EGFP expression in PBMC by FACS. (Cooperation with CrownBio)

Validation data of DTR function

Heterozygous Cd19-IRES-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. After the tumors grew to 100 mm3, the Cd19-IRES-DTRGFP mice were injected with Diphtheria toxin. 

Cd19-2.png

Fig2. The growth of MC38 tumors in Heterozygous Cd19-IRES-DTRGFP mice and C57BL/6 mice. (Cooperation with CrownBio)

Cd19-3.png

Fig3. The percent of CD19+ cell in peripheral blood of MC38 tumor-bearing Cd19-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. (Cooperation with CrownBio)

Cd19-4.png

Fig4. The percent of CD19+ cell in peripheral blood of MC38 tumor-bearing Cd19-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. (Cooperation with CrownBio)

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