hFCRN(2)
系統名
C57BL/6Smoc-Fcgrtem2(hFCGRT)Smoc
SMOC番号
NM-HU-190070
維持形態
Repository Live
遺伝子の概要
Gene Symbol
FCGRT
Gene Symbol
Fcgrt
説明
表現型データ
Fig1. Validation of hFCGRT and mFCGRT expression in humanized Fcgrt mice by Western blot. These results showed that hFCGRT can be expressed in the liver and kidney of humanized Fcgrt homozygous and heterozygous mice，while mFCGRT can not be expressed in the humanized Fcgrt homozygous mice.
Fig2. Blood concentration curves of Keytruda in C57BL/6 and hFcRn KI mice. (n=3/time point/group)
Fig3. Blood concentration curves of Cyramza(A) and Keytruda(B) in C57BL/6, hFcRn KI and Fcgrt-KO mice.(n=3/time point/group)
Fig4. In vivo PK profiles of TAA scfv-anti HSA VHH in hALB/hFCRN mice(NM-HU-200278) (female, 10-12weeks, n=3 mice/timepoint), which were generated by crossing hFCRN(NM-HU-190070) with hALB(NM-HU-200003). (In cooperation with the third party).
Fig5. Blood concentration curves of test articles in C57BL/6 and hFcRn/hALB dKI mice(NM-HU-200278) , which were generated by crossing hFCRN(NM-HU-190070) with hALB(NM-HU-200003).(In cooperation with the third party)
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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