hCSF1R(2)
系統名
C57BL/6Smoc-Csf1rem3(hCSF1R)Smoc
SMOC番号
NM-HU-190074
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
CSF1R
説明
表現型データ
Fig1. Detection of CSF1R(2) expression in spleen by RT-PCR. Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2));Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of hCSF1R expression in blood and bone marrow in hCSF1R(2) KI mice.
Fig3. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in hCSF1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.(FPA008,BMS,phase II)
Fig4. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in hCSF1R mice.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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