hCSF1R(2)

系統名

C57BL/6Smoc-Csf1rem3(hCSF1R)Smoc

SMOC番号

NM-HU-190074

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
CSF1R

Synonyms

Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359

NCBI ID

12978

MGI ID

1339758

Ensembl ID

ENSMUSG00000024621

Pubmed

CSF1R

Human Ortholog

CSF1R

説明

The endogenous mouse Csf1r gene was replaced by human CSF1R gene. While hCSF1R (Stock No.NM-HU-00094) have been pulled from shelves for some reasons.
応用分野：Immunotherapy,Cancer research,Drug screening

表現型データ

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Fig1. Detection of CSF1R(2) expression in spleen  by RT-PCR. Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2));Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Detection of hCSF1R expression in blood and bone marrow in hCSF1R(2) KI mice.

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Fig3. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in hCSF1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008，BMS，phase II）

验证数据-CSFIR-HU-图2.png

Fig4. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in hCSF1R mice.

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