Lat-Y136F

系統名

C57BL/6Smoc-Latem1(Y136F）Smoc

SMOC番号

NM-KI-200249

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol
Lat

Synonyms

pp36; p36-38

NCBI ID

16797

MGI ID

1342293

Ensembl ID

ENSMUSG00000030742

Pubmed

Lat

Human Ortholog

LAT

説明

These mice carry a p.Y136F mutation of Lat gene.

応用分野：IgG4-related diseases

病気の予測

Igg4-Related Disease

表現型

MGI:2385971

参考文献

Aguado E, et al., Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science. 2002 Jun 14;296(5575):2036-40

表現型データ

image.png

Fig1. Spleen (left) and mesenteric lymph nodes (right) from 8-week-old wild-type and Lat-Y136F mice.

image.png

Fig2. Immunotype in Lat-Y136F mice in lymph nodes.

image.png

Fig3. Immunotype in Lat-Y136F mice in peripheral blood.

image.png

Fig4. Immunotype in Lat-Y136F mice in spleen.

image.png

Fig5. Immunotype in Lat-Y136F mice in thymus.

image.png

Fig6. Analysis of mIgE expression in the serum by ELISA in WT C57BL/6 and HO Lat-Y136F mice (female, 8-9wks, n=5). 

The expression of mIgE in the serum increased significantly in the homozygous KI mouse.

image.png

Fig7. Analysis of mIgG1 expression in the serum by ELISA in WT C57BL/6 and HO Lat-Y136F mice (female, 8-9wks, n=5). 

The expression of mIgG1 in the serum increased significantly in the homozygous KI mouse.

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細