hEPCAM

系統名

C57BL/6Smoc-EpCAMtm1(hEpCAM)Smoc

SMOC番号

NM-HU-210032

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Epcam

Synonyms

EGP; Ly74; gp40; CD326; EGP-2; TROP1; Egp314; Ep-CAM; EpCAM1; Tacsd1; GA733-2; Tacstd1

NCBI ID

17075

MGI ID

106653

Ensembl ID

ENSMUSG00000045394

Pubmed

Epcam

Human Ortholog

EPCAM

説明

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.
応用分野：inmmue therapy；drug screening

表現型データ

1.png

Fig1. Analysis of mouse EPCAM and human EPCAM protein expression in the large intestine by IHC. Both the EPCAM humanized heterozygous mouse and wild type express mouse EPCAM in the mucosal epithelial membranes, and the humanized heterozygous mouse  expresses human EPCAM in the crypts significantly.

2.pngFig2. Analysis of mouse EPCAM and human EPCAM protein expression in the small intestine by IHC. Both the EPCAM humanized heterozygous mouse and wild type express mouse EPCAM in the mucosal epithelial membranes, and the humanized heterozygous mouse  expresses human EPCAM in the crypts significantly.

image.png

Fig3. Detection of human EpCAM expression in WT C57 and homozygous hEpCAM mice by IHC. Small intestine were collected from wild-type mice (+/+) and homozygous hEpCAM mice (HO/HO), and analyzed by IHC with anti-human EpCAM antibody. 

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