Ccr2-IRES-DTRGFP
系統名
C57BL/6Smoc-Ccr2em1(IRES-DTRGFP)Smoc
SMOC番号
NM-KI-210102
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Ccr2
説明
表現型データ
Fig1. Analysis of GFP expression in the Ccr2-IRES-DTRGFP mice by FACS. The expression of GFP could be detected in CCR2+ and CD11b+ cells in peripheral blood of the heterozygous KI mice.
Fig2. Analysis of CCR2+/CD11b+ cells proportion and GFP level in Ccr2-IRES-DTRGFP mice by FACS. The heterozygous KI mice were treated with DT (qd x 3 days).After 2 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells in the peripheral blood were decreased, and the level of GFP positive cells also decreased. After 4 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells returned to normal, and the level of GFP positive cells also returned to normal.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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