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Models

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

マウス
H11-pAlb-hHAO1
系統名：C57BL/6JSmo-Igs2tm1(pAlb-hHAO1 CDS-hHAO1 3'UTR-pA)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-231910
マウス
H11-pK18-hACE2
系統名：C57BL/6JSmo-Igs2tm(pK18-hACE2)1Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-225001
マウス
H11-pT3(b)-hIL15-Flag
系統名：C57BL/6JSmo-Igs2tm(pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-220128
マウス
H11-pThy1-hPSEN1-IRES-tdTomato
系統名：C57BL/6JSmo-Igs2tm1(pThy1-PSEN1-IRES-tdTomato-WPRE-pA)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-18049
応用分野：Alzheimer's research
マウス
h4-1BB(2)
系統名：C57BL/6JSmo-Tnfrsf9tm2(TNFRSF9)Smoc
維持形態：Repository Live | SMOC番号：NM-HU-190077
応用分野：Immunotherapy,Cancer research,Drug screening
マウス
h4-1BB(2)/h4-1BBL
系統名：C57BL/6JSmo-Tnfrsf9tm2(TNFRSF9)Tnfsf9tm1(hTNFSF9)Smoc
維持形態：Repository Live | SMOC番号：NM-HU-234521
マウス
h4-1BB(2)/hCD3E(2)
系統名：C57BL/6JSmo-Tnfrsf9tm2(TNFRSF9)Cd3etm2(hCD3E)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-HU-210409
応用分野：Drug Screening; Immunotherapy Evaluation
マウス
h4-1BB(2)/hOX40
系統名：C57BL/6JSmo-Tnfrsf9tm2(TNFRSF9)Tnfrsf4tm1(hTNFRSF4)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-HU-200272
マウス
h4-1BB(2)/hPD-1
系統名：C57BL/6JSmo-Tnfrsf9tm2(h4-1BB)Pdcd1tm1(hPDCD1)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-HU-200279
マウス
h4-1BB(2)/hPD-1/hPD-L1
系統名：C57BL/6JSmo-Tnfrsf9tm2(TNFRSF9)Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)/Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-HU-210357
応用分野：inmmue therapy；drug screening
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