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Models

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

マウス
Avil-LSL-hM3Dq-mCherry
系統名：C57BL/6JSmo-Avilem1(LSL-Kozak-hM3Dq-mCherry-WPRE-pA)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-232881
マウス
CAG-hACE2-IRES-Luc-Tg
系統名：C57BL/6JSmo-Tgtn(CAG-human ACE2-IRES-Luciferase-WPRE-polyA)Smoc
維持形態：Repository Live | SMOC番号：NM-TG-200002
応用分野：corona virus related research
マウス
CMV-hIL34-Tg(NMG)
系統名：NOD.Cg-PrkdcscidIl2rgem1Tg(pCMV-hIL34-pA)1Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-TG-220433
マウス
H11-CAG-LSL-hACHE
系統名：C57BL/6JSmo-Igs2tm1(CAG-LSL-ACHE-WPRE-pA)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-00067
応用分野：Cholinesterase related drug research
マウス
H11-CAG-LSL-hHTTQ148-hHTT 3'UTR
系統名：C57BL/6JSmo-Igs2tm1(CAG-loxP-STOP-loxP-hHTTQ148-hHTT 3'UTR-pA)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-234493
マウス
H11-CAG-LSL-hLILRB4-IRES-EGFP
系統名：C57BL/6JSmo-Igs2tm1(CAG-loxP-STOP-loxP-hLILRB4-IRES-EGFP-WPRE-pA)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-230387
マウス
H11-CAG-LSL-hPSEN1-IRES-tdTomato
系統名：C57BL/6JSmo-Igs2tm1(CAG-LSL-PSEN1-IRES-tdTomato-WPRE-polyA)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-190110
応用分野：Alzheimer's research
マウス
H11-CAG-LSL-LSL-hMYCN-IRES-EGFP
系統名：C57BL/6JSmo-Igs2tm1(CAG-loxp-Neo-Stop-loxp-lox2272-Neo-Stop-lox2272-HA tag-NMYC-IRES-EFGP-WPRE-polyA)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210145
応用分野：Cancer research
マウス
H11-pAlb-hALB-IRES-Luc
系統名：C57BL/6JSmo-Igs2tm1(ALB promoter-human ALB-IRES-Luciferase-polyA)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-200322
マウス
H11-pAlb-hBAFF
系統名：C57BL/6JSmo-Igs2tm1(pAlb-hBAFF-pA)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-232137
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