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Models

About 42,523 results
マウス

Axl-KO

系統名:C57BL/6Smoc-Axlem1Smoc
維持形態:Repository Live | SMOC番号:NM-KO-200044

Exon 3 of Axl gene was deleted to generate Axl knockout mice.

マウス

CD8a-IRES-Luc-2A-tdTomato(BALB/c)

系統名:BALB/cAnSmoc-CD8aem5(IRES-Akaluc-2A-tdTomato)Smoc
維持形態:Embryo cryopreservation | SMOC番号:NM-KI-200208

A IRES-luci-2A-tdTomato expression cassette was knocked into the CD8a gene stop codon site.

マウス

hCD3E(2)

系統名:C57BL/6Smoc-Cd3eem2(hCD3E)Smoc
維持形態:Embryo cryopreservation | SMOC番号:NM-HU-210023

The endogenous mice Cd3e gene was replaced by human CD3E gene. While hCD3E(Stock No.NM-HU-00114) mice function similarly to hCD3E(2) mice,for more detailed information please contact our technical advisor.

マウス

hTNFR2/hPD-1

系統名:C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1) /Smoc
維持形態:Embryo cryopreservation | SMOC番号:NM-HU-210407

hTNFRSF1B(NM-HU-190010) was crossed with hPD-1(NM-HU-00015)to generate hTNFRSF1B/hPD-1 mice

マウス

hFAS

系統名:C57BL/6Smoc-Fasem1(hTNFRSF6)/Smoc
維持形態:Sperm cryopreservation | SMOC番号:NM-HU-210007

The endogenous mice Fas gene was replaced by human FAS gene.

マウス

KPC

系統名:C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
維持形態:Repository Live | SMOC番号:NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

マウス

hCXCR2

系統名:C57BL/6Smoc-Cxcr2em2(hCXCR2)Smoc
維持形態:Embryo cryopreservation | SMOC番号:NM-HU-18025

The endogenous mouse Cxcr2 gene was replaced by human CXCR2 gene.

マウス

R26-CAG-LSL-dCas9-VPR-IRES-EGFP

系統名:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-dCas9-VPR-IRES-EGFP-WPRE-pA)
維持形態:Repository Live | SMOC番号:NM-KI-18004

These mice harbor a CAG-LSL-dCas9-VPR(VP64-p65-Rta)-eGFP-pA conditional expression cassette in mouse Rosa26 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

マウス

hCD3E/hSDC1

系統名:C57BL/6Smoc-Cd3eem1(hCD3E)Sdc1em1(hSDC1)/Smoc
維持形態:Embryo cryopreservation | SMOC番号:NM-HU-220021

hCD3E(NM-HU-00114) was crossed with hSDC1(NM-HU-2000026) to generate hCD3E/hSDC1 mice.

マウス

R26-LSL-hIL15-Flag-IRES-EGFP

系統名:C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-Loxp-Stop-Loxp-Kozak-hIL2 signal peptide-hIL15-Flag-IRES-EGFP-polyA)Smoc
維持形態:Sperm cryopreservation | SMOC番号:NM-KI-220130

CAG-Loxp-Stop-Loxp-Kozak-hIL2 signal peptide-hIL15-Flag-IRES-EGFP-polyA expression cassette was knocked into the the Rosa26 locus

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