hFCRN/hALB(SD)

系統名

SD-Fcgrtem1(hFCGRT)Albem3(hALB)Smoc

SMOC番号

NR-HU-233317

維持形態

Developing

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遺伝子の概要

説明

The hALB(SD)(NR-HU-200001) was crossed with hFCRN(SD)(NR-HU-200002) to generate hFCRN(SD)/hALB(SD) mice.

表現型データ

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Fig.1 Detection of ALB expression in serum by blood biochemical analysis (n=4). 

Abbr. HO, homozygous; WT, wild type.


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Fig.2 Detection of hALB (A) and rALB (B) expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

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Fig.3 Expression characterization of hFCRN in hALB/hFCRN dKI rat by Western blot. (Arrow indicates expected molecular weight and asterisk indicates a nonspecific band)   


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Fig.4  Blood concentration curve of test articles in hFcRn/hALB dKI rats. 

In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party) 


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Fig.5 PK study of Keytruda in  hALB/hFCRN dKl rat. (n=3/time point/group)  


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Fig.6 PK study of Cyramza in hALB/hFCRN dKI rat. (n=3/time point/group)  

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