Ace2-2A-CreERT2

系統名

C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc

SMOC番号

NM-KI-200187

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
ACE2

Synonyms

ACEH

NCBI ID

59272

MGI ID

Null

Ensembl ID

ENSG00000130234

Pubmed

ACE2

Human Ortholog

ACE2

説明

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.
応用分野：Cre recombinase tool

表現型データ

image.png

Fig. 1 CreERT2-mediated recombination in the lung of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary bronchial epithelial cells of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

image.png

Fig. 2 CreERT2-mediated recombination in the kidney of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the proximal tubule of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 


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