Pah-KO

系統名

C57BL/6Smoc-Pahem1Smoc

SMOC番号

NM-KO-2110565

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Pah

Synonyms

AW106920

NCBI ID

18478

MGI ID

97473

Ensembl ID

ENSMUSG00000020051

Pubmed

Pah

Human Ortholog

PAH

説明

Exon 2-5 of pah gene was deleted to generate pah knockout mice.

病気の予測

Phenylketonuria

表現型

MGI:6715269

参考文献

Singh K, et al., CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria. Sci Rep. 2021 Mar 31;11(1):7254

表現型データ

image.png

Fig1. Characterization of WT C57BL/6 and Pah-KO mice. 

(A) The Pah-KO mice showed lower body weights than the WT mice (n=20/group). (B) Summary of blood Phe at various timepoints is shown (n=20/group). (C) Summary of blood Tyr at various timepoints is shown (n=20/group). Note: Data from the third party.

image.png

Fig2. Hair coat color in WT C57BL/6 and Pah-KO mice. 

Hair coat of the Pah-KO mouse is light brown whereas it is dark brown for the WT C57BL/6 mouse.

Note: Data from the third party.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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