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Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

マウス
Raf1-D486N
系統名：C57BL/6JSmo-Raf1em1(D486N)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-200252
応用分野：Noonan syndrome
マウス
Ripk1-D138N
系統名：C57BL/6JSmo-Ripk1em1(D138N)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-200280
マウス
Ryr1-R4884C
系統名：C57BL/6JSmo-Ryr1em(R4884C)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-225075
マウス
Ryr2-R1760W
系統名：C57BL/6JSmo-Ryr2tm1(R1760W)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-230112
マウス
Scn1a-c.473+5G>A
系統名：C57BL/6JSmo-Scn1aem1(c.473+5G>A)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210417
マウス
Setx-P1674L
系統名：C57BL/6JSmo-Setxem1(P1674L)Smoc
維持形態：Developing | SMOC番号：NM-KI-232087
マウス
Slc6a1-S295L
系統名：C57BL/6JSmo-Slc6a1em2(S295L)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-190014
応用分野：Nervous system, Immune system, Genetic epilepsy, Rare disease
マウス
Sod1-G94A
系統名：C57BL/6JSmo-Sod1em1(G94A)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-232083
マウス
Spink1-c.197+2t>c
系統名：C57BL/6JSmo-Spink1em1c.197+2t>cSmoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-232249
マウス
Tardbp-M337V
系統名：C57BL/6JSmo-Tardbpem1(M337V)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-232085
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