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Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

マウス
hHBB-E7V
系統名：C57BL/6JSmo-hHBBtm1(E7V)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-233577
マウス
hMAPT-P301S
系統名：C57BL/6JSmo-Mapttm1(hMAPT-P301S)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-233262
マウス
Ifng-del(162bp)
系統名：C57BL/6JSmo-Ifngem1(162bp-del)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210223
マウス
Il6st-Y757F/V760A
系統名：C57BL/6JSmo-Il6stem(Y757F-V760A)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-220045
マウス
Ins2-C96Y
系統名：C57BL/6JSmo-Ins2em3(C96Y)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-190096
病気の予測：diabetes
マウス
Jak2-Flox-V617F
系統名：C57BL/6JSmo-Jak2tm1(Flox-V617F)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210367
マウス
Jak2-Flox-V617F(2)
系統名：C57BL/6JSmo-Jak2em(flox-V617F)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-220009
マウス
Kit-V831M
系統名：C57BL/6JSmo-Kitem2(V831M)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-190023
応用分野：hematopoieticstem cell 
マウス
Kit-V831M(NOD-scid)
系統名：NOD-PrkdcscidKitem1(V831M)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-200316
応用分野：Hematopoieticstem cell
マウス
Kras-LSL-G12D
系統名：C57BL/6JSmo-Krasem4(LSL-G12D)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-190003
病気の予測：squamous cell carcinoma, prostate cancer, pancreatic carcinoma, neurofibromatosis, pancreatic ductal adenocarcinoma, juvenile myelomonocytic leukemia, urinary bladder cancer, ovarian cancer
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