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Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

マウス
Mdm4-C462A
系統名：B6;129S-Mdm4tm1Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-00007
マウス
Muc2-C987Y
系統名：C57BL/6JSmo-Muc2em1C987YSmoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-234203
マウス
Mvd-F250S
系統名：C57BL/6JSmo-Mvdtm(F250S)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210368
マウス
Myh6-R404Q
系統名：C57BL/6JSmo-Myh6em1(R404Q)Smoc
維持形態：Repository Live | SMOC番号：NM-KI-215054
マウス
Naglu-A198V
系統名：C57BL/6JSmo-Nagluem1(A198V)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-232081
マウス
Naglu-R531X
系統名：C57BL/6JSmo-Nagluem1(R531X)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-232082
マウス
Nefl-N98S
系統名：C57BL/6JSmo-Neflem1(N98S)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-200251
病気の予測：Charcot-Marie-Tooth disease type 2E
マウス
Nlrp3-LSL-A350V
系統名：C57BL/6JSmo-Nlrp3tm(LSL-A350V)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210365
マウス
Notch3-R170C
系統名：C57BL/6JSmo-Notch3em1(R170C)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-200254
病気の予測：CADASIL 1
マウス
Npc1-I1060T
系統名：C57BL/6JSmo-Npc1em1(I1060T)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-18059
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