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Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

マウス
Kras-RSR-G12D
系統名：C57BL/6JSmo-Krastm(Rox-Stop-Rox-G12D)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-210436
マウス
Lat-Y136F
系統名：C57BL/6JSmo-Latem1(Y136F）Smoc
維持形態：Repository Live | SMOC番号：NM-KI-200249
病気の予測：IgG4-related disease
マウス
Ldlr-C223R
系統名：C57BL/6JSmo-Ldlrem1(C223R)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-00043
応用分野：Metabolic and cardiovascular disease research
マウス
Lep-R105X
系統名：C57BL/6JSmo-Lepem(R105X)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-230475
マウス
Lep-R105X(BALB/c)
系統名：BALB/cJSmo-Lepem(R105X)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-230476
マウス
Lepr-g.G109052T
系統名：B6.129S-Leprtm1Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-00001
応用分野：Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.
マウス
Lmna-c.C1827T
系統名：C57BL/6JSmo-Lmnatm1(G609G)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-200284
病気の予測：progeria
マウス
Lrrk2-P1446L
系統名：C57BL/6JSmo-Lrrk2em(P1446L)Smoc
維持形態：Embryo cryopreservation | SMOC番号：NM-KI-215098
マウス
Mapt-R5H
系統名：C57BL/6JSmo-Maptem(R5H)Smoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-215099
マウス
Mcm7-R43Q
系統名：C57BL/6JSmo-Mcm7em1R43QSmoc
維持形態：Sperm cryopreservation | SMOC番号：NM-KI-233284
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